• EDIM TECHNOLOGY EXAMINES MONOCYTES AND MACROPHAGES

    For this purpose, CD14 and CD16 surface antibodies are used, which bind specifically to the surface of the cells. The cells are then permeabilised briefly to induce further antibodies to enter the cells. These antibodies are directed against the antigens which are to be detected by the method. If there is an EDIM detect, TKTL1 and Apo10 are channelled into the cells. The cell structures on the surface of cells can be recognised very efficiently in blood samples with dye-labelled antibodies and a subsequent detection of these dyes by means of laser beams using a flow cytometry method. This makes it possible to recognise, count and further characterise scavengers in the blood. In this way, signals are also detected which are derived from bound antibodies in the cell interior. This makes it possible to detect what the phagocyte has detected and eliminated by phagocytosis. If there are tumour cells in the organism, the system detects signals from the dyes that are coupled to the TKTL1 and Apo10 antibodies.

  • AUTOMATED EVALUATION OF THE MEASUREMENT DATA!

    The hitherto elaborate evaluation using gating for the detection of the different cell populations and the delineation of the antigen-positive monocytes and macrophages against antigen-negative cells will in the future be replaced by mathematical algorithms and image recognition programmes.